Purinostat [CAS 1929583-17-4]
Purinostat [CAS 1929583-17-4]
SKU:QM-0007352-01
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Product Details
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Description
Purinostat is a selective inhibitor of HDAC I/IIb with anti-leukemic activity. Purinostat mesylate , the mesylate salt of Purinostat, inhibits the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDAC I/IIb to inhibit several important factors for leukemic stem cell (LSC) survival, including c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Purinostat mesylate increases glutamate metabolism in LSC by increasing GLS1[1].
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CAS Number
[1929583-17-4]
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Molecular Formula
C23H26N10O3
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Molecular Weight
490.52
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Smiles
O=C(C1=CN=C(N(CC2=NC3=C(N4CCOCC4)N=C(C5=CC=C(N)C=C5)N=C3N2C)C)N=C1)NO
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Target
HDAC
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Isoform
HDAC1; HDAC2
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Purity
98.04
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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Purinostat [CAS 1929583-17-4]
Purinostat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.