Quizartinib (Standard) [CAS 950769-58-1]
Quizartinib (Standard) [CAS 950769-58-1]
SKU:QM-0086090-01
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Product Details
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Description
Quizartinib (Standard) is the analytical standard of Quizartinib. This product is intended for research and analytical applications. Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis[1].
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CAS Number
[950769-58-1]
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Molecular Formula
C29H32N6O4S
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Molecular Weight
560.67
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Smiles
O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
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Target
Apoptosis; Autophagy; FLT3; Ligands for Target Protein for PROTAC; Reference Standards
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Shipping Conditions
Room temperature
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Quizartinib (Standard) [CAS 950769-58-1]
Quizartinib (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.