(R) -CR8 (trihydrochloride) [CAS 1786438-30-9]
(R) -CR8 (trihydrochloride) [CAS 1786438-30-9]
SKU:QM-0154952-01
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Product Details
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Description
(R) -CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R) -CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM) . (R) -CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R) -CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K[3].
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CAS Number
[1786438-30-9]
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Molecular Formula
C24H32Cl3N7O
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Molecular Weight
540.92
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Smiles
CC[C@@H](NC1=NC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4N=CN(C(C)C)C4=N1)CO.[H]Cl.[H]Cl.[H]Cl
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Target
Apoptosis; CDK; Molecular Glues
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Isoform
CDK1; CDK2; CDK5; CDK7; CDK9
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Concentration
10mM
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Purity
99.37
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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(R) -CR8 (trihydrochloride) [CAS 1786438-30-9]
(R) -CR8 (trihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.