Rencofilstat [CAS 1383420-08-3]
Rencofilstat [CAS 1383420-08-3]
SKU:QM-0145138-01
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Product Details
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Description
Rencofilstat (CRV431) is an orally active pan-cyclophilin inhibitor with IC50 values of 2.5 nM, 3.1 nM, 2.8 nM, 7.3 nM for Cyp A, CypB, Cyp D and Cyp G, respectively. Rencofilstat reduces fibrosis and tumor growth in models of chronic liver disease. Rencofilstat can be used for the study of nonalcoholic steatohepatitis (NASH), hepatocellular carcinoma and viral hepatitis-induced liver disease[1].
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CAS Number
[1383420-08-3]
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Molecular Formula
C67H122N12O13
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Molecular Weight
1303.76
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Smiles
O[C@@H]([C@](C(N[C@H](C(N([C@@H](C(N([C@H](C(N[C@H](C(N([C@H]1CC(C)C)C)=O)C(C)C)=O)CC(C)C)C)=O)C)C)=O)CC)=O)([H])N(C([C@@H](N(C([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC1=O)C)=O)C)=O)C)CC(C)C)=O)C)CC(C)C)=O)C)C(C)C)=O)C)[C@H](C)CCCCCCNC(C)=O
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Target
Cyclophilin; Interleukin Related; Nuclear Factor of activated T Cells (NFAT) ; Sirtuin
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Isoform
Cyclophilin A; Cyclophilin B; Cyclophilin D; Cyclophilin G
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Purity
90.29
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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Rencofilstat [CAS 1383420-08-3]
Rencofilstat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.