Rhosin (hydrochloride) [CAS 1281870-42-5]
Rhosin (hydrochloride) [CAS 1281870-42-5]
SKU:QM-0141913-01
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Product Details
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Description
Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis[1][2]. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3].
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CAS Number
[1281870-42-5]
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Molecular Formula
C20H19ClN6O
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Molecular Weight
394.86
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Smiles
O=C(N/N=C/C1=CC=C2N=CC=NC2=C1)[C@H](N)CC3=CNC4=C3C=CC=C4.[H]Cl
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Target
Apoptosis; Ras
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Purity
99.94
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Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Rhosin (hydrochloride) [CAS 1281870-42-5]
Rhosin (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.