Ritlecitinib (tosylate) [CAS 2192215-81-7]
Ritlecitinib (tosylate) [CAS 2192215-81-7]
SKU:QM-0079661-01
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Product Details
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Description
Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M) . Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) [1][2][3].
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CAS Number
[2192215-81-7]
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Molecular Formula
C22H27N5O4S
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Molecular Weight
457.55
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Smiles
CC(C=C1)=CC=C1S(O)(=O)=O.C=CC(N2[C@@H](C)CC[C@@H](NC3=C4C(NC=C4)=NC=N3)C2)=O
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Target
Interleukin Related; JAK; STAT
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Isoform
IL-15; IL-2; IL-4; IL-7; JAK3; STAT3; STAT5; STAT6
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Purity
99.77
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Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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Ritlecitinib (tosylate) [CAS 2192215-81-7]
Ritlecitinib (tosylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.