Ro 31-8220 (mesylate) [CAS 138489-18-6]
Ro 31-8220 (mesylate) [CAS 138489-18-6]
SKU:QM-0146396-01
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Product Details
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Description
Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5].
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CAS Number
[138489-18-6]
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Molecular Formula
C26H27N5O5S2
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Molecular Weight
553.65
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Smiles
NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O
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Target
JNK; PKC
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Isoform
PKC; PKCα; PKCβ; PKCγ; PKCε
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Concentration
10mM
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Purity
99.57
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Solubility
DMSO : 35.71 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Ro 31-8220 (mesylate) [CAS 138489-18-6]
Ro 31-8220 (mesylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.