RO2959 (hydrochloride) [CAS 1219927-22-6]
RO2959 (hydrochloride) [CAS 1219927-22-6]
SKU:QM-0138172-01
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Product Details
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Description
RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2].
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CAS Number
[1219927-22-6]
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Molecular Formula
C21H19F2N5OS.xHCl
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Smiles
O=C(NC1=NC=C(C2=C(C)CCN(C3=NC=C(C)S3)C2)N=C1)C4=C(F)C=CC=C4F.[xHCl]
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Target
CRAC Channel; Interleukin Related
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Isoform
IL-2
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Purity
98
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Solubility
10 mM in DMSO
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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RO2959 (hydrochloride) [CAS 1219927-22-6]
RO2959 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.