Rocaglamide [CAS 84573-16-0]
Rocaglamide [CAS 84573-16-0]
SKU:QM-0076878-01
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Product Details
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Description
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia[1][2][3].
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CAS Number
[84573-16-0]
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Molecular Formula
C29H31NO7
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Molecular Weight
505.56
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Smiles
O[C@]12[C@](OC3=CC(OC)=CC(OC)=C32)(C4=CC=C(C=C4)OC)[C@H](C5=CC=CC=C5)[C@H]([C@H]1O)C(N(C)C)=O
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Target
Eukaryotic Initiation Factor (eIF) ; HSP; NF-κB
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Isoform
EIF4; HSF1
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Purity
99.34
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Rocaglamide [CAS 84573-16-0]
Rocaglamide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.