Rosuvastatin [CAS 287714-41-4]
Rosuvastatin [CAS 287714-41-4]
SKU:QM-0000643-01
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Product Details
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Description
Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].
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CAS Number
[287714-41-4]
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Molecular Formula
C22H28FN3O6S
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Molecular Weight
481.54
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Smiles
O=C(O)C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2
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Target
Autophagy; Bacterial; HMG-CoA Reductase (HMGCR) ; Potassium Channel
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Purity
99.67
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Solubility
DMSO : ≥ 100 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Rosuvastatin [CAS 287714-41-4]
Rosuvastatin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.