Rosuvastatin-d3 [CAS 1133429-16-9]
Rosuvastatin-d3 [CAS 1133429-16-9]
SKU:QM-0073885
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Product Details
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Description
Rosuvastatin-d3 (ZD 4522-d3) is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].
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CAS Number
[1133429-16-9]
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Molecular Formula
C22H25D3FN3O6S
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Molecular Weight
484.56
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Smiles
FC(C=C1)=CC=C1C2=NC(N(C([2H])([2H])[2H])S(=O)(C)=O)=NC(C(C)C)=C2/C=C/[C@@H](O)C[C@@H](O)CC(O)=O
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Target
Autophagy; HMG-CoA Reductase (HMGCR) ; Isotope-Labeled Compounds; Potassium Channel
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Rosuvastatin-d3 [CAS 1133429-16-9]
Rosuvastatin-d3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.