Rosuvastatin-d6 [CAS 2070009-40-2]
Rosuvastatin-d6 [CAS 2070009-40-2]
SKU:QM-0012801
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Product Details
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Description
Rosuvastatin-d6 (ZD 4522-d6) is deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].
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CAS Number
[2070009-40-2]
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Molecular Formula
C22H22D6FN3O6S
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Molecular Weight
487.57
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Smiles
OC(C[C@H](O)C[C@H](O)/C=C/C1=C(C(C([2H])([2H])[2H])C([2H])([2H])[2H])N=C(N(C)S(C)(=O)=O)N=C1C2=CC=C(C=C2)F)=O
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Target
Autophagy; Bacterial; HMG-CoA Reductase (HMGCR) ; Isotope-Labeled Compounds; Potassium Channel
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Shipping Conditions
Room temperature
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Rosuvastatin-d6 [CAS 2070009-40-2]
Rosuvastatin-d6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.