(S) -PFI-2 (hydrochloride) [CAS 1627607-88-8]
(S) -PFI-2 (hydrochloride) [CAS 1627607-88-8]
SKU:QM-0136756-01
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Product Details
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Description
(S) -PFI-2 hydrochloride is an inhibitor of lysine methyltransferase SETD7 and is approximately 500-fold more active than its enantiomer (R) -PFI-2. (R) -PFI-2 is a cofactor-dependent and substrate-competitive inhibitor. (R) -PFI-2 can occupy the substrate peptide binding groove of SETD7 (including the catalytic lysine binding channel) and interact with the cofactor The donor methyl group is in direct contact. However, (S) -PFI-2 was not observed to have the same interaction as (R) -PFI-2[1][2].
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CAS Number
[1627607-88-8]
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Molecular Formula
C23H26ClF4N3O3S
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Molecular Weight
535.98
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Smiles
O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.Cl
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Target
Histone Methyltransferase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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(S) -PFI-2 (hydrochloride) [CAS 1627607-88-8]
(S) -PFI-2 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.