(S, R, S) -AHPC (dihydrochloride) [CAS 2137142-47-1]
(S, R, S) -AHPC (dihydrochloride) [CAS 2137142-47-1]
SKU:QM-0057145
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Product Details
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Description
(S, R, S) -AHPC (VH032-NH2) dihydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S, R, S) -AHPC dihydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475) . GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].
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CAS Number
[2137142-47-1]
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Molecular Formula
C22H32Cl2N4O3S
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Molecular Weight
503.49
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Smiles
O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl.Cl
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Target
Ligands for E3 Ligase
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Isoform
Von Hippel-Lindau (VHL)
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H315-H319-H335
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Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
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(S, R, S) -AHPC (dihydrochloride) [CAS 2137142-47-1]
(S, R, S) -AHPC (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.