(S, R, S) -AHPC-Me (hydrochloride) [CAS 1948273-03-7]
(S, R, S) -AHPC-Me (hydrochloride) [CAS 1948273-03-7]
SKU:QM-0156188-01
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Product Details
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Description
(S, R, S) -AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S, R, S) -AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S, R, S) -AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 [2].
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CAS Number
[1948273-03-7]
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Molecular Formula
C23H33ClN4O3S
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Molecular Weight
481.05
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Smiles
N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl
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Target
Ligands for E3 Ligase
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Isoform
Von Hippel-Lindau (VHL)
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Purity
99.95
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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(S, R, S) -AHPC-Me (hydrochloride) [CAS 1948273-03-7]
(S, R, S) -AHPC-Me (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.