(S) -Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C (CH3) 3
(S) -Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C (CH3) 3
SKU:QM-0080196
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Product Details
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Description
(S) -Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C (CH3) 3 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide and the corresponding Linker. (S) -Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C (CH3) 3 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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Molecular Formula
C33H42N8O7
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Molecular Weight
662.74
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Smiles
O=C1NC(CC[C@@H]1N2C(C3=C(C=CC(N4CCN(CC4)C5=NC=NC(N6CCN(CC6)CCOCC(OC(C)(C)C)=O)=C5)=C3)C2=O)=O)=O
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Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
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Isoform
Cereblon
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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(S) -Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C (CH3) 3
(S) -Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C (CH3) 3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.