SB 220025 (tri (hydrochloride) ) [CAS 197446-75-6]
SB 220025 (tri (hydrochloride) ) [CAS 197446-75-6]
SKU:QM-0096719
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Product Details
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Description
SB 220025 trihydrochloride is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC50 = 60 nM) . SB 220025 trihydrochloride also inhibits p56Lck and PKC with IC50 values of 3.5 and 2.89 μM, respectively. SB 220025 trihydrochloride inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 trihydrochloride effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation[1][2].
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CAS Number
[197446-75-6]
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Molecular Formula
C18H22Cl3FN6
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Molecular Weight
447.76
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Smiles
NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCNCC4)=N1.Cl.Cl.Cl
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Target
P38 MAPK; PKC; Src
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Shipping Conditions
Room temperature
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Hazard Statement
H315-H319-H320
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Precautions
P264-P280-P302+P352-P305+P351+P338-P362
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SB 220025 (tri (hydrochloride) ) [CAS 197446-75-6]
SB 220025 (tri (hydrochloride) ) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.