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Semapimod [CAS 352513-83-8]
Semapimod [CAS 352513-83-8]
SKU:QM-0071547
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Product Details
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Description
Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC50≈0.3 μM) . Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders[1][2][3].
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CAS Number
[352513-83-8]
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Molecular Formula
C34H52N18O2
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Molecular Weight
744.9
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Smiles
O=C(NC1=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C1)CCCCCCCCC(NC2=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C2)=O
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Target
Interleukin Related; p38 MAPK; TNF Receptor
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Isoform
IL-1; IL-6; p38 MAPK; TNFRSF5/CD40
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Semapimod [CAS 352513-83-8]
Semapimod is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.