Semapimod (tetrahydrochloride) [CAS 164301-51-3]
Semapimod (tetrahydrochloride) [CAS 164301-51-3]
SKU:QM-0007631-01
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Product Details
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Description
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM) . Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3].
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CAS Number
[164301-51-3]
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Molecular Formula
C34H56Cl4N18O2
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Molecular Weight
890.74
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Smiles
O=C(NC1=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C1)CCCCCCCCC(NC2=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C2)=O.Cl.Cl.Cl.Cl
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Target
Interleukin Related; p38 MAPK; TNF Receptor
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Isoform
IL-1; IL-6; p38 MAPK; TNFRSF5/CD40
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Purity
98.43
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Solubility
H2O : 2.17 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H312, H315, H319, H332, H335
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Precautions
H302, H312, H315, H319, H332, H335
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Semapimod (tetrahydrochloride) [CAS 164301-51-3]
Semapimod (tetrahydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.