Simvastatin acid [CAS 121009-77-6]
Simvastatin acid [CAS 121009-77-6]
SKU:QM-0059694-01
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Product Details
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Description
Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin , is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
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CAS Number
[121009-77-6]
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Molecular Formula
C25H40O6
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Molecular Weight
436.58
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Smiles
O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(C)(CC)C)=O)C)C)O)O)O
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Target
HMG-CoA Reductase (HMGCR) ; Reactive Oxygen Species (ROS)
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Purity
99.66
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Blue Ice
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Simvastatin acid [CAS 121009-77-6]
Simvastatin acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.