Simvastatin acid-d6 (ammonium)
Simvastatin acid-d6 (ammonium)
SKU:QM-0059695
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Product Details
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Description
Simvastatin acid-d6 (ammonium) mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5) . Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
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Molecular Formula
C25H37D6NO6
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Molecular Weight
459.65
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Smiles
O=C(C[C@@H](C[C@@H](CC[C@@]1([H])[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(CC)(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C)C)O)O)[O-].[NH4+]
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Target
Endogenous Metabolite; Isotope-Labeled Compounds
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Simvastatin acid-d6 (ammonium)
Simvastatin acid-d6 (ammonium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.