Siramesine (hydrochloride) [CAS 224177-60-0]
Siramesine (hydrochloride) [CAS 224177-60-0]
SKU:QM-0147752-01
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Product Details
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Description
Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM) . Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
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CAS Number
[224177-60-0]
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Molecular Formula
C30H32ClFN2O
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Molecular Weight
491.04
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Smiles
FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1.Cl
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Target
Ferroptosis; Sigma Receptor
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Isoform
Sigma 1 Receptor
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Purity
99.69
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Solubility
DMSO : ≥ 42 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Siramesine (hydrochloride) [CAS 224177-60-0]
Siramesine (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.