SLM6031434 (hydrochloride) [CAS 1897379-34-8]
SLM6031434 (hydrochloride) [CAS 1897379-34-8]
SKU:QM-0139856-01
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Product Details
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Description
SLM6031434 hydrochloride is the hydrochloride salt form of SLM6031434. SLM6031434 is a highly selective sphingosine kinase 2 (SphK2) inhibitor with an IC50 value of 0.4 μM for SphK2. SLM6031434 exerts anti-fibrotic effects by increasing sphingosine accumulation and Smad7 expression. SLM6031434 demonstrates effective anti-fibrotic efficacy in a unilateral ureteral obstruction (UUO) -induced tubulointerstitial fibrosis mouse model. SLM6031434 can be used for the study of proteinuric kidney diseases or chronic kidney disease (CKD)[2].
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CAS Number
[1897379-34-8]
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Molecular Formula
C22H31ClF3N5O2
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Molecular Weight
489.96
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Smiles
N=C(N1[C@H](C2=NC(C(C=C3)=CC(C(F)(F)F)=C3OCCCCCCCC)=NO2)CCC1)N.Cl
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Target
SphK
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Isoform
SphK1; SphK2
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Purity
99.1
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Solubility
H2O : 40 mg/mL (ultrasonic; warming)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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SLM6031434 (hydrochloride) [CAS 1897379-34-8]
SLM6031434 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.