Sorafenib (tosylate) (Standard) [CAS 475207-59-1]
Sorafenib (tosylate) (Standard) [CAS 475207-59-1]
SKU:QM-0081749-01
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Product Details
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Description
Sorafenib tosylate (Standard) is the analytical standard of Sorafenib tosylate. This product is intended for research and analytical applications. Sorafenib tosylate (Bay 43-9006 tosylate) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib tosylate induces autophagy and apoptosis. Sorafenib Tosylate has anti-tumor activity. Sorafenib tosylate is a ferroptosis activator[1].
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CAS Number
[475207-59-1]
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Molecular Formula
C28H24ClF3N4O6S
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Molecular Weight
637.03
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Smiles
O=S(C1=CC=C(C)C=C1)(O)=O.O=C(NC2=CC=C(C=C2)OC3=CC(C(NC)=O)=NC=C3)NC4=CC=C(Cl)C(C(F)(F)F)=C4
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Target
Apoptosis; Autophagy; Ferroptosis; FLT3; Raf; Reference Standards; VEGFR
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Shipping Conditions
Room temperature
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Sorafenib (tosylate) (Standard) [CAS 475207-59-1]
Sorafenib (tosylate) (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.