STAT3/CAIX-IN-1 [CAS 3053583-60-8]
STAT3/CAIX-IN-1 [CAS 3053583-60-8]
SKU:QM-0012048
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Product Details
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Description
STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (Kd: 60.03 μM) and CAIX (IC50: 80.45 nM) . STAT3/CAIX-IN-1 induces ferroptosis by increases the levels of reactive oxygen species (ROS) and lipid peroxides. STAT3/CAIX-IN-1 inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 can be used for the study of triple-negative breast cancer (TNBC) [1].
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CAS Number
[3053583-60-8]
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Molecular Formula
C28H23F6N5O5S2
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Molecular Weight
687.63
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Smiles
O=C(NC1=NN=C(S(=O)(N)=O)S1)CCCC(N2C/C(C(/C(C2)=C/C3=CC=C(C(F)(F)F)C=C3)=O)=C\C4=CC=C(C(F)(F)F)C=C4)=O
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Target
Apoptosis; Bcl-2 Family; Carbonic Anhydrase; Caspase; Ferroptosis; Reactive Oxygen Species (ROS) ; STAT
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Isoform
CA; CA II; CA IX; STAT3
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Shipping Conditions
Room temperature
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STAT3/CAIX-IN-1 [CAS 3053583-60-8]
STAT3/CAIX-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.