STAT3-D11-PROTAC-VHL
STAT3-D11-PROTAC-VHL
SKU:QM-0010934-01
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Product Details
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Description
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting Signal Transducer and Activator of Transcription 3 (STAT3) . STAT3-D11-PROTAC-VHL exhibits anti-tumor activity with IC50 values of 1335 nM and 1973 nM against HeLa and MCF-7 cells, respectively. STAT3-D11-PROTAC-VHL binds to the DNA-binding domain of STAT3 and recruits the E3 ligase VHL to form a ternary complex, leading to the ubiquitination of STAT3 and subsequent degradation by the proteasome. STAT3-D11-PROTAC-VHL also inhibits tumor cell growth, induces cell cycle arrest and apoptosis, and suppresses tumor immune evasion[1].
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Smiles
[STAT3-D11-PROTAC-VHL]
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Target
Apoptosis; PROTACs; STAT
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Isoform
STAT3
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Purity
96.33
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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STAT3-D11-PROTAC-VHL
STAT3-D11-PROTAC-VHL is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.