STAT3-IN-11 [CAS 2503096-50-0]
STAT3-IN-11 [CAS 2503096-50-0]
SKU:QM-0149950-01
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Product Details
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Description
STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers[1].
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CAS Number
[2503096-50-0]
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Molecular Formula
C20H17NO4
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Molecular Weight
335.35
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Smiles
O=C(NCCC(C1=O)=C(C)C(C2=C1C(O)=CC=C2)=O)C3=CC=CC=C3
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Target
Apoptosis; STAT
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Purity
98.29
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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STAT3-IN-11 [CAS 2503096-50-0]
STAT3-IN-11 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.