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STAT3-IN-18 [CAS 2668267-41-0]
STAT3-IN-18 [CAS 2668267-41-0]
SKU:QM-0072051
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Product Details
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Description
STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.
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CAS Number
[2668267-41-0]
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Molecular Formula
C18H24Cl2N2O6Pt
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Molecular Weight
630.38
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Smiles
[Cl-][Pt+4]([Cl-])([NH3])([NH3])([OH-])[O-]C(COC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2)=O
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Target
Apoptosis; COX; JAK; STAT
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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STAT3-IN-18 [CAS 2668267-41-0]
STAT3-IN-18 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.