STAT3-IN-20 [CAS 2768427-54-7]
STAT3-IN-20 [CAS 2768427-54-7]
SKU:QM-0076240-01
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Product Details
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Description
STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM) . STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively) . STAT3-IN-20 induces cell cycle arrest and apoptosis[1].
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CAS Number
[2768427-54-7]
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Molecular Formula
C30H27F4N7S
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Molecular Weight
593.64
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Smiles
FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1
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Target
STAT
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Purity
99.83
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Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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STAT3-IN-20 [CAS 2768427-54-7]
STAT3-IN-20 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.