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STAT3-IN-27
STAT3-IN-27
SKU:QM-0088309
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Product Details
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Description
STAT3-IN-27 (Compound 41) is an orally active inhibitor for phosphorylation of STAT3 (KD is 4.4 μM) and STAT3 transcription (IC50 is 22.57 nM) . STAT3-IN-27 inhibits proliferation of various cancer cells with IC50 of 10-500 nM. STAT3-IN-27 arrests the cell cycle at G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116, inhibits cell migration of HCT116. STAT3-IN-27 exhibits antitumor efficacy in mouse model[1].
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Molecular Formula
C18H21N3O4S
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Molecular Weight
375.44
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Smiles
O=C(C1C2ON=C1C)C3=C(C=C(C(NCCCN4CCCC4)=O)S3)C2=O
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Target
Apoptosis; STAT
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Shipping Conditions
Room temperature
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STAT3-IN-27
STAT3-IN-27 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.