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STAT3-IN-38 [CAS 3033049-16-7]
STAT3-IN-38 [CAS 3033049-16-7]
SKU:QM-0094274
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Product Details
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Description
STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33 µM) . STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1) . STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells[1].
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CAS Number
[3033049-16-7]
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Molecular Formula
C35H45NO3S
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Molecular Weight
559.8
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Smiles
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(NCCC4=CC=CS4)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
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Target
Apoptosis; STAT; Survivin
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Isoform
STAT3
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Shipping Conditions
Room temperature
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STAT3-IN-38 [CAS 3033049-16-7]
STAT3-IN-38 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.