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STAT3-IN-46
STAT3-IN-46
SKU:QM-0013412
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Product Details
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Description
STAT3-IN-46 is a selective and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3) (KD = 323.3 nM) . STAT3-IN-46 directly binds to the SH2 domain of the STAT3 and inhibits IL-6/JAK/STAT3 signaling pathway (IC50 = 0.87 μM) and downregulates c-Myc and Bcl-2 levels. STAT3-IN-46 can be used for the research of cancer, such as triple-negative breast cancer[1].
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Molecular Formula
C31H29FN8S
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Molecular Weight
564.68
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Smiles
N#CC1=CC=CC(C2=NN=C(NC3=C(N4CCN(CC)CC4)C=C5N(C6CC6)C(C7=CC=C(F)C=C7)=NC5=C3)S2)=C1
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Target
Bcl-2 Family; c-Myc; Interleukin Related; JAK; STAT
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Isoform
Bcl-2; IL-6; STAT3
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Shipping Conditions
Room temperature
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STAT3-IN-46
STAT3-IN-46 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.