STAT3-IN-52 [CAS 1556861-34-7]
STAT3-IN-52 [CAS 1556861-34-7]
SKU:QM-0014908-01
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Product Details
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Description
STAT3-IN-52 (Compound 9) is a selective and orally active signal transducer and activator of transcription 3 (STAT3) inhibitor. STAT3-IN-52 binds to the pY705 site of STAT3 (Ki = 440 nM), blocking the phosphorylation and dimerization of STAT3. STAT3-IN-52 shows strong cytotoxicity against various cancer cells, such as breast cancer MDA-MB-231 (IC50 = 0.7 μM), medulloblastoma UW426, pancreatic cancer BKPC3 cells. STAT3-IN-52 can induce cell apoptosis, inhibit the STAT3 nuclear transport and DNA binding activity and downregulate the expression of the STAT3 target gene MMP9. STAT3-IN-52 can be used for research related to STAT3 abnormal activation in cancer[1].
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CAS Number
[1556861-34-7]
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Molecular Formula
C20H20N4O4S
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Molecular Weight
412.46
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Smiles
O=S(C(C=CC=C1C(C(NC2=CC=CC=C2N3CCNCC3)=C4)=O)=C1C4=O)(N)=O
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Target
Apoptosis; MMP; STAT
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Isoform
MMP-9; STAT3
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Shipping Conditions
Room temperature
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STAT3-IN-52 [CAS 1556861-34-7]
STAT3-IN-52 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.