STAT3/NF-κB-IN-1
STAT3/NF-κB-IN-1
SKU:QM-0012956
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Product Details
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Description
STAT3/NF-κB-IN-1 is a potentSTAT3 and NF-κB inhibitor with IC50s of 5.86 (STAT3) and 4.22 μM (NF-κB) in 4T1 cells. STAT3/NF-κB-IN-1 is able to induce apoptosis via its upregulation on key apoptotic regulators; caspases-3/9, Bax and downregulation of Bcl-2. STAT3/NF-κB-IN-1 exerts considerable anticancer activity against breast cancer cell lines and reduces tumor volume in vivo. STAT3/NF-κB-IN-1 can be used for the study of breast cancer[1].
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Molecular Formula
C27H26N8O3S
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Molecular Weight
542.61
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Smiles
CCN1C(SCC(N/N=C\C2=CN(N=C2C3=CC=CC=C3)C4=CC=CC=C4)=O)=NC5=C1C(N(C(N5C)=O)C)=O
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Target
Apoptosis; Bcl-2 Family; Caspase; NF-κB; STAT
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Isoform
Bax; Bcl-2; Caspase 3; Caspase 9; NF-κB; STAT3
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Shipping Conditions
Room temperature
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STAT3/NF-κB-IN-1
STAT3/NF-κB-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.