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TAK-960 (hydrochloride) [CAS 1137868-96-2]
TAK-960 (hydrochloride) [CAS 1137868-96-2]
SKU:QM-0000536
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Product Details
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Description
TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 hydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts[1].
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CAS Number
[1137868-96-2]
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Molecular Formula
C27H34F3N7O3.xClH
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Smiles
O=C(NC1CCN(C)CC1)C2=CC(OC)=C(NC3=NC=C(N4C)C(N(C5CCCC5)CC(F)(F)C4=O)=N3)C=C2F.[xHCl]
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Target
Polo-like Kinase (PLK)
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Isoform
PLK1; PLK2; PLK3
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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TAK-960 (hydrochloride) [CAS 1137868-96-2]
TAK-960 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.