Tamoxifen-13C6 [CAS 1346606-38-9]
Tamoxifen-13C6 [CAS 1346606-38-9]
SKU:QM-0054574-01
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Product Details
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Description
Tamoxifen-13C6 (ICI 47699-13C6) is the 13C-labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[5]. Tamoxifen activates autophagy and induces apoptosis[4]. Tamoxifen also can induce gene knockout of CreER transgenic mouse[6].
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CAS Number
[1346606-38-9]
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Molecular Formula
C20 13C6H29NO
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Molecular Weight
377.47
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Smiles
[H][13C]1=[13CH][13CH]=[13C](/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)/C3=CC=CC=C3)[13CH]=[13CH]1
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Target
Apoptosis; Autophagy; Estrogen Receptor/ERR; HSP; Isotope-Labeled Compounds
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Shipping Conditions
Room temperature
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Tamoxifen-13C6 [CAS 1346606-38-9]
Tamoxifen-13C6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.