Tamoxifen-d3 (hydrochloride)
Tamoxifen-d3 (hydrochloride)
SKU:QM-0146051-01
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Product Details
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Description
Tamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[5]. Tamoxifen Citrate activates autophagy and induces apoptosis[4].Tamoxifen Citrate also can induce gene knockout of CreER (T2) transgenic mouse[6].
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Molecular Formula
C26H27D3ClNO
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Molecular Weight
410.99
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Smiles
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C([2H])([2H])[2H])C)C=C2)\C3=CC=CC=C3.Cl
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Target
Apoptosis; Autophagy; Estrogen Receptor/ERR; HSP; Isotope-Labeled Compounds
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Purity
98.99
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Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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Tamoxifen-d3 (hydrochloride)
Tamoxifen-d3 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.