TASIN-1 (hydrochloride) [CAS 1678515-13-3]
TASIN-1 (hydrochloride) [CAS 1678515-13-3]
SKU:QM-0103995
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Product Details
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Description
TASIN-1 hydrochloride is a selective inhibitor of truncated APCTR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 hydrochloride specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 hydrochloride exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 hydrochloride can be used to prevent and intervene in APC mutant colorectal cancer[1][2][3].
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CAS Number
[1678515-13-3]
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Molecular Formula
C18H29ClN2O3S
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Molecular Weight
388.95
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Smiles
CC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1.Cl
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Target
Apoptosis; Caspase; JNK; Reactive Oxygen Species (ROS)
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Isoform
Caspase 3; Caspase 7
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Shipping Conditions
Room temperature
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TASIN-1 (hydrochloride) [CAS 1678515-13-3]
TASIN-1 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.