Tazemetostat [CAS 1403254-99-8]
Tazemetostat [CAS 1403254-99-8]
SKU:QM-0146166-01
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Product Details
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Description
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2) -containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells[1].
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CAS Number
[1403254-99-8]
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Molecular Formula
C34H44N4O4
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Molecular Weight
572.74
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Smiles
O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
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Target
Apoptosis; Histone Methyltransferase
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Isoform
EZH2
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Purity
99.93
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Solubility
DMSO : 58.33 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Tazemetostat [CAS 1403254-99-8]
Tazemetostat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.