Telaglenastat (hydrochloride) [CAS 1874231-60-3]
Telaglenastat (hydrochloride) [CAS 1874231-60-3]
SKU:QM-0060224
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Product Details
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Description
Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat hydrochloride inudces autophagy and has antitumor activity[1].
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CAS Number
[1874231-60-3]
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Molecular Formula
C26H25ClF3N7O3S
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Molecular Weight
608.04
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Smiles
[H]Cl.O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
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Target
Autophagy; Glutaminase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Telaglenastat (hydrochloride) [CAS 1874231-60-3]
Telaglenastat (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.