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TH5427 (hydrochloride) [CAS 2253744-57-7]
TH5427 (hydrochloride) [CAS 2253744-57-7]
SKU:QM-0060629
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Product Details
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Description
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM) . TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1].
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CAS Number
[2253744-57-7]
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Molecular Formula
C20H21Cl3N8O3
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Molecular Weight
527.79
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Smiles
[H]Cl.O=C(N1C)N(C)C2=C(N(CC3=NN=C(C4=CC=C(Cl)C(Cl)=C4)O3)C(N5CCNCC5)=N2)C1=O
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Target
DNA/RNA Synthesis
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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TH5427 (hydrochloride) [CAS 2253744-57-7]
TH5427 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.