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THZ1 (Hydrochloride)
THZ1 (Hydrochloride)
SKU:QM-0157070-01
£136.38 GBP
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Product Details
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Description
THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression[1][2].
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Molecular Formula
C31H29Cl2N7O2
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Molecular Weight
602.51
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Smiles
ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(/C=C/CN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54.Cl
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Target
CDK
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Isoform
CDK12; CDK13; CDK7
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Purity
99.06
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Solubility
DMSO : 116.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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THZ1 (Hydrochloride)
THZ1 (Hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.