Tizanidine (hydrochloride) [CAS 64461-82-1]
Tizanidine (hydrochloride) [CAS 64461-82-1]
SKU:QM-0157710-01
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Product Details
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Description
Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α2-adrenoceptor agonist (IC50 = 6.9 nmol) . Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI) [1][2][3][4].
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CAS Number
[64461-82-1]
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Molecular Formula
C9H9Cl2N5S
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Molecular Weight
290.17
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Smiles
ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1.Cl
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Target
Adrenergic Receptor; Akt; Apoptosis; Wnt; β-catenin
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Isoform
α adrenergic receptor
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Purity
99.93
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Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 20 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Tizanidine (hydrochloride) [CAS 64461-82-1]
Tizanidine (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.