TMI-1 (Standard) [CAS 287403-39-8]
TMI-1 (Standard) [CAS 287403-39-8]
SKU:QM-0002377
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Product Details
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Description
TMI-1 (Standard) is the analytical standard of TMI-1. This product is intended for research and analytical applications. TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions[1][2][3][4].
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CAS Number
[287403-39-8]
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Molecular Formula
C17H22N2O5S2
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Molecular Weight
398.5
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Smiles
O=C([C@@H]1N(S(=O)(C2=CC=C(OCC#CC)C=C2)=O)CCSC1(C)C)NO
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Target
Apoptosis; Caspase; Interleukin Related; MMP; Reference Standards; TNF Receptor
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Shipping Conditions
Room temperature
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TMI-1 (Standard) [CAS 287403-39-8]
TMI-1 (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.