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Tomivosertib (hydrochloride) [CAS 1849590-02-8]
Tomivosertib (hydrochloride) [CAS 1849590-02-8]
SKU:QM-0079030
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Product Details
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Description
Tomivosertib hydrochlorideis a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib hydrochloride treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines[1]. Tomivosertib hydrochloride also dramatically downregulates PD-L1 protein abundance[2].
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CAS Number
[1849590-02-8]
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Molecular Formula
C17H21ClN6O2
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Molecular Weight
376.84
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Smiles
O=C(C1=C(C)C=C(NC2=NC=NC(N)=C2)C(N13)=O)NC43CCCCC4.Cl
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Target
MNK; PD-1/PD-L1
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Shipping Conditions
Room temperature
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Tomivosertib (hydrochloride) [CAS 1849590-02-8]
Tomivosertib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.