Trifluridine/tipiracil hydrochloride mixture [CAS 733030-01-8]
Trifluridine/tipiracil hydrochloride mixture [CAS 733030-01-8]
SKU:QM-0153786-01
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Product Details
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Description
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha, alpha, alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI) . Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA[1][2].
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CAS Number
[733030-01-8]
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Molecular Formula
C10H11F3N2O5.1/2C9H11ClN4O2.1/2HCl
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Molecular Weight
435.76
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Smiles
O=C1N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(C(F)(F)F)C(N1)=O.O=C3NC(CN4CCCC4=N)=C(Cl)C(N3)=O.[1/2].Cl
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Target
Nucleoside Antimetabolite/Analog; Thymidylate Synthase
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Purity
99.98
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Solubility
DMF : 20 mg/mL (ultrasonic) |DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Trifluridine/tipiracil hydrochloride mixture [CAS 733030-01-8]
Trifluridine/tipiracil hydrochloride mixture is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.