Trimebutine-d5 (fumarate) [CAS 2747915-18-8]
Trimebutine-d5 (fumarate) [CAS 2747915-18-8]
SKU:QM-0158164-01
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Product Details
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Description
Trimebutine-d5 fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) [1][2][3][4][5][6][7].
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CAS Number
[2747915-18-8]
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Molecular Formula
C26H28D5NO9
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Molecular Weight
508.57
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Smiles
OC(/C=C/C(O)=O)=O.O=C(C1=CC(OC)=C(C(OC)=C1)OC)OCC(C([2H])([2H])C([2H])([2H])[2H])(C2=CC=CC=C2)N(C)C
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Target
Akt; Apoptosis; Calcium Channel; ERK; IRAK; Isotope-Labeled Compounds; JNK; NF-κB; Opioid Receptor; Potassium Channel; Toll-like Receptor (TLR)
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Isoform
ERK1; ERK2; IRAK1; L-type calcium channel; μ Opioid Receptor/MOR
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Trimebutine-d5 (fumarate) [CAS 2747915-18-8]
Trimebutine-d5 (fumarate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.