Trimethylamine N-oxide (dihydrate) [CAS 62637-93-8]
Trimethylamine N-oxide (dihydrate) [CAS 62637-93-8]
SKU:QM-0136295-01
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Product Details
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Description
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].
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CAS Number
[62637-93-8]
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Molecular Formula
C3H13NO3
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Molecular Weight
111.14
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Smiles
C[N+](C)([O-])C.[2H2O]
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Target
Endogenous Metabolite; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; TGF-beta/Smad
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Isoform
Human Endogenous Metabolite; Microbial Metabolite; NLRP3
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Concentration
10mM
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Purity
99.86
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319
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Precautions
H315, H319
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Trimethylamine N-oxide (dihydrate) [CAS 62637-93-8]
Trimethylamine N-oxide (dihydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.