TRV055 (hydrochloride)
TRV055 (hydrochloride)
SKU:QM-0201322-01
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Product Details
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Description
TRV055 (TRV120055) (hydrochloride) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs) . TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses[1][2].
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Molecular Formula
C42H58ClN9O9
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Molecular Weight
868.42
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Smiles
O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC(CN)=O)=O)CC(C=C3)=CC=C3O)=O)=O)CC4=CN=CN4.[H]Cl
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Target
Angiotensin Receptor
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Isoform
AT1 Receptor
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Purity
98.88
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Solubility
H2O : ≥ 50 mg/mL
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Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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TRV055 (hydrochloride)
TRV055 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.