TrxR/EGFR-IN-1 [CAS 3038386-42-1]
TrxR/EGFR-IN-1 [CAS 3038386-42-1]
SKU:QM-0008550-01
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Product Details
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Description
TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib -sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib (HY-50895) -resistant lung cancer[1].
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CAS Number
[3038386-42-1]
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Molecular Formula
C24H24AuClFN6O2P
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Molecular Weight
710.88
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Smiles
ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(OCC#C[Au][P]45CN6CN(CN(C6)C5)C4)C(OC)=C3)=C1
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Target
Apoptosis; EGFR; Ferroptosis; TrxR
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Shipping Conditions
Room temperature
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TrxR/EGFR-IN-1 [CAS 3038386-42-1]
TrxR/EGFR-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.